Background: Osteoarthritis (OA) can affect all three compartments of the knee, but epidemiological studies have shown that the predominant pattern is disease localized to the medial side of the knee, although a lot of studies had been done to compare different modalities of treatment, the gold standard treatment for AMOA is not yet well known and the decision of which procedure is best suited to an individual, or whether an individual would be prepared to undergo one type of surgery, but not another is a complex issue. Aim of the work: This study is a systematic review and meta-analysis of studies that include patients underwent medial UKA for treating isolated medial knee osteoarthritis, and to provide cumulative data about the efficacy and safety of Uni-compartmental knee arthroplasty (UKA) in treating isolated medial compartment knee osteoarthritis Patients and Methods: This review was done using standard methodology outlined in the Cochrane Handbook and reported the findings in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement guidelines, (PubMed, Cochrane library and Google Scholar) were searched for relative studies which studied the outcome of Pre-operative status versus Post-operative sequel of medial compartment knee osteoarthritis patients by estimating Mean, Standard deviation (± SD) and range for parametric numerical data, while Median, Geometric Mean and Inter-quartile range (IQR) for non-parametric numerical data, Frequency and percentage of non-numerical data and their 95% confidence intervals for each study. Results: 10 studies studied the outcome of Pre-operative status versus Post-operative sequel of medial compartment knee osteoarthritis were obtained for final research, in these studies 2304 knees underwent UKA, we qualitatively assessed 1ry efficacy outcome by assessing prevalence of moderate to severe pain and functional knee score (ROM – range of motion) and qualitatively assessed 2ry safety outcome by measuring complications rate, revision surgery (Failure) rate and survival probability %. Conclusions: UKA is a solution that is adapted to the treatment of unicompartmental osteoarthritis AMOA in old patients more than 60 years of age, this intervention provides the patient with excellent quality of life and satisfaction in more than 90% of the cases.
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