STUDY THE ASSOCIATION BETWEEN SERUM ASYMETRICAL DIMETHYLARGININE LEVEL AND CARDIAC FUNCTIONS IN CHRONIC KIDNEY DISEASE PATIENTS

Abdelmobdy, Ashraf Hassan; Abdelwahab, Saeed; Sallam, Walid Mohamed; Mahmoud, Mostafa Ashour

doi:10.21608/asmj.2022.270148

STUDY THE ASSOCIATION BETWEEN SERUM ASYMETRICAL DIMETHYLARGININE LEVEL AND CARDIAC FUNCTIONS IN CHRONIC KIDNEY DISEASE PATIENTS

Document Type : Original Article

Authors

¹ Internal Medicine Department,

² Cardiology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

³ Nephrology Department, National Institute of Nephrology, Cairo, Egypt.

10.21608/asmj.2022.270148

Abstract

Background: It is well known that cardiovascular disease is the leading cause of death for those who suffer from chronic renal disease, making it a pressing global public health concern. Human blood contains a naturally occurring modified amino acid called asymmetric dimethylarginine (ADMA). It may have a significant role in the development of atherosclerosis by preventing the body from producing nitric oxide, a gas essential for maintaining healthy vascular tone.
Aim of the work: This research aimed to examine the correlation between ADMA levels in the blood and heart function as measured by tissue Doppler imaging in patients with chronic renal disease.
Patients and methods: Ninety individuals were enrolled in our study from the National Institute of Nephrology and Urology's outpatient clinics and inpatient units. All patients underwent a thorough history and physical examination as well as laboratory tests, echocardiography, and Tissue Doppler imaging.
Results: There are a highly significant difference among three groups as regard as serum Creatinine level, estimated glomerular filtration rate (eGFR), serum calcium, Parathyroid hormone, serum ADMA, interventricular septal diameter (IVSD), left atrial diameter (LAD), Septal Peak E' and Lateral Peak E'. There is a positive correlation with between ADMA and serum phosphorus, and a negative correlation between ADMA and lateral peak E'.
Conclusion: Tissue Doppler imaging is considered to be more accurate than echocardiography in estimating diastolic function, and serum ADMA is inversely correlated with diastolic function in chronic kidney disease (CKD) patients.

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