Effect of Early and Late Platelet Rich Plasma Therapy in Experimental Chronic Liver Disease: Role of Lipid profile.

Document Type : Original Article

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Physiology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Abstract

Background: Chronic liver disease is a public health problem in Egypt. Thioacetamide (TAA), a hepatotoxin causing damage resembling that of the human, allows proper evaluation of new therapeutic approaches such as platelet rich plasma (PRP). Lipid profile was suggested as a prognostic indicator in patients with advanced liver disease. Aim of work: To evaluate the effect of early and late PRP treatment on the markers of liver injury including lipid profile, in Thioacetamide-induced chronic liver diseased rats. Materials and methods: Sixty female albino rats were divided into 4 weeks group and 6 weeks group; each group was further divided into 3 subgroups; -TAA group: given TAA twice weekly for 4 weeks in both the 4 and 6 weeks groups. -TAA-PRP group: PRP was given, immediately after TAA for 4 weeks in the 4 weeks early treated group or started 2 weeks after TAA for 4 weeks in the 6 weeks late treated group. -Control group.
Biochemical assessment included ALT, AST, Albumin, lipid profile, Malondialdehyde (MDA), Total antioxidant capacity (TAC), and hepatic MDA and glutathione peroxidase (GPx). Results: Both TAA groups showed significant elevation of serum ALT, AST, serum and hepatic MDA and significant reduction of serum albumin and lipid profile. Early and late treatment with PRP, significantly improved the liver enzymes and serum and hepatic MDA. Albumin was normalized in early treated group while plasma TC and LDL-C were normalized in late treated group. Conclusion: PRP treatment successfully improved liver enzymes, lipid profile, albumin as well as oxidative stress.

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Ain Shams Medical Journal
Volume 74, Issue 1
March 2023
Pages 263-280

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