GLYCEMIC CHARACTERISTICS AND CLINICAL OUTCOME IN A SAMPLE OF EGYPTIAN COVID-19 PATIENTS WITH OR WITHOUT DIABETES

Abdalla, Amira Emeel; El Khawaga, Salwa Seddik; Bahaa El Din, Ahmed Mohamed; Adly, Nahla Nader; Abd El Hady, Amr Mahmoud Mohamed

doi:10.21608/asmj.2023.298367

GLYCEMIC CHARACTERISTICS AND CLINICAL OUTCOME IN A SAMPLE OF EGYPTIAN COVID-19 PATIENTS WITH OR WITHOUT DIABETES

Document Type : Original Article

Authors

Department of Internal Medicine and Endocrinology, Faculty of Medicine, Ain Shams University., Cairo, Egypt.

10.21608/asmj.2023.298367

Abstract

Background: The high prevalence of diabetes globally makes it a frequent comorbidity in patients with coronavirus-associated disease 2019 (COVID-19. As is often identified as an independent risk factor for developing lower respiratory tract infections Aim of work: This study aims to describe the glycemic characteristics and clinical outcomes in a sample of Egyptian COVID-19 patients with or without diabetes. Patients and Methods: A cross-sectional study on 160 patients in chest out-patient clinic of Kafr el sheikh chest hospital divided to 2 groups: 80 diabetic covid-19 patients and 80 non-diabetic covid-19patients. All candidates were subjects to history, laboratory investigations (FPG, 2hrsPP, HbA1c, RT-PCR, CRP, D-dimer, Serum ferritin, Serum cholesterol, Serum Urea, Serum creatinine, SGOT, SGPT and Oxygen saturation. Evaluation of the clinical outcome whether recovery after home isolation and treatment, hospitalization in isolation hospitals, or ICU admission. Results: Statistically significant higher in Diabetic than non-Diabetic covid -19 patients regarding Age, BMI, Chest CT and Prognosis, D-dimer(mg/l), S. Ferritin, CRP, O2 saturation, SGOT, SGPT, S. cholesterol, S. urea, S. creatinine and DKA/HHS. Age, BMI, D-dimer, S. Ferritin, CRP, SGOT, SGPT, S. cholesterol, S.urea and S. creatinine are positively correlated with FBG while O2 saturation is negatively correlated with FBG. A highly statistically significant difference found between home treated, hospital admitted and ICU admitted groups regarding Age, BMI, Chest CT, PCR, FBG, 2HPP, D-dimer, S. Ferritin, CRP, O2 saturation, SGOT, SGPT, S. cholesterol, S.urea, S. creatinine and DKA/HHS being higher I ICU admitted followed by hospital admitted then home treated patients. Serum ferritin was the most predictive factor for ICU admission. Conclussions: Diabetic patients are more susceptible to severe COVID-19 infection, and show higher levels of inflammatory markers. Serum ferritin is highly sensitive predictors of need for ICU admission..

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