PLATELET/ LYMPHOCYTE RATIO (PLR) PREDICTIVE VALUE IN IMMUNE THROMBOCYTOPENIC PURPURA PATIENTS

Document Type : Original Article

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Internal Medicine and Clinical Hematology Department, Faculty of Medicine, Ain Shams University, Egypt.

Abstract

Background: platelet/lymphocyte ratio (PLR) is a new inflammatory marker, and its level increases in different inflammatory diseases, diabetes, and malignancy. In ITP patients, there is a decrease in platelet count, and theories suggest an inflammatory response from the immune system toward platelets mastered by lymphocytes.
Aim of the work: The study aimed to know the relation between platelet /lymphocytes and correlate this ratio to the prognosis of immune thrombocytopenia Patients and Methods: This was a retrospective study conducted on 96 subjects diagnosed with immune thrombocytopenic purpura attending the haematology unit of Ain Shams University, divided into 2 groups (responsive ITP group and resistant/relapsed), with data collected at the time of diagnosis and after 3 months of treatment and follow-up in comparison to 32 subjects in the control group. Results: In comparison between ITP sub-groups at the time of diagnosis, responsive ITP group patients had a significantly higher PLR compared to other groups, while resistant or relapsed ITP patients had a significantly lower PLR. After 3 months of treatment, PLR revealed that resistant or relapsed ITP patients had a significantly lower PLR compared to other groups (P 0.001). Conclusion: A low level of PLR is an indicator of ITP resistance or the development of relapse.

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