Study the Association between Serum Asymetrical Dimethylarginine Level and Cardiac Functions in Chronic kidney Disease Patients

Abdelmobdy, Ashraf Hassan; Sallam, Walid; Mahmoud, Mostafa; Abdelwahab, Saeed

doi:10.21608/asmj.2022.157013.1038

Study the Association between Serum Asymetrical Dimethylarginine Level and Cardiac Functions in Chronic kidney Disease Patients

Articles in Press

Document Type : Original Article

Authors

¹ Internal Medicine Department, Faculty of Medicine Ain Shams University, Cairo, Egypt.

² Cardiology department, Faculty of Medicine Ain Shams University, Cairo, Egypt.

³ National Institute of Nephrology, Cairo, Egypt.

⁴ Internal Medicine and Nephrology; Nephrology department, Faculty of Medicine Ain Shams University, Cairo, Egypt

10.21608/asmj.2022.157013.1038

Abstract

Background: It is well known that cardiovascular disease is the leading cause of death for those who suffer from chronic renal disease, making it a pressing global public health concern. Human blood contains a naturally occurring modified amino acid called asymmetric dimethylarginine (ADMA). It may have a significant role in the development of atherosclerosis by preventing the body from producing nitric oxide, a gas essential for maintaining healthy vascular tone.
Objectives: This research aimed to examine the correlation between ADMA levels in the blood and heart function as measured by tissue Doppler imaging in patients with chronic renal disease.
Patients and methods: Ninety individuals were enrolled in our study from the National Institute of Nephrology and Urology's outpatient clinics and inpatient units. All patients underwent a thorough history and physical examination as well as laboratory tests, echocardiography, and Tissue Doppler imaging.
Results: There are a highly significant difference among three groups as regard as serum Creatinine level, estimated GFR, serum calcium PTH, serum ADMA, IVSD, LAD, Septal Peak E' and Lateral Peak E'. There is a positive correlation with between ADMA and serum PO, and a negative correlation between ADMA and lateral peak E.
Conclusion: Tissue Doppler imaging is considered to be more accurate than echocardiography in estimating diastolic function, and serum ADMA is inversely correlated with diastolic function in CKD patients.

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