Clinical Relevance of RUNX1 Mutation in Primary Refractory Egyptian Acute Myeloid Leukemia Patients.

Rakha, Nahed Moawad; Ahmed, Shaza; A.elsamee, Hanaa; Mousa, Reham

doi:10.21608/asmj.2022.163458.1050

Clinical Relevance of RUNX1 Mutation in Primary Refractory Egyptian Acute Myeloid Leukemia Patients.

Articles in Press

Document Type : Original Article

Authors

¹ Clinical Hematology Unite, Internal Medicine Department, Faculty of Medicine, Ain Shams University

² Clinical Hematology and Bone Marrow Transplantation Unit, Faculty of medicine, Ain shams university, Cairo, Egypt.

10.21608/asmj.2022.163458.1050

Abstract

Background: Primary refractory acute myeloid leukemia (AML) represents a continuing obstacle in clinical management. The Runt-related transcription factor 1 (RUNX1) gene is a relatively uncommon mutational target in AML cases.
Aim: to investigate the role of RUNX1 mutation in newly diagnosed refractory AML patients receiving first-line induction chemotherapy.
Methods: Our research involved 50 newly diagnosed Egyptian AML patients; As a control group, 20 newly diagnosed AML patients who received the conventional first induction chemotherapy with complete remission (CR) and 30 newly diagnosed AML patients who received the same conventional first induction chemotherapy protocols but did not respond to the treatment.
Results: 13.3% of the examined cases group had RUNXI mutations found, compared to 5% of the control group, RUNXI mutation was found statistically significant with cases group (P=0.01) and RUNX1 mutation and OS were significantly correlated (P=0.05).
Conclusion: RUNX1 mutation have a role in resistance to treatment and prognosis in AML. Therefore, measurement of RUNX1 level provides a new strategy to more aggressive treatments for primary refractory AML cases.

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