Effects of Whole Body Cooling and Magnesium Sulfate on Infants with Hypoxic-Ischemic Encephalopathy Treatment

Ayed, Manal Mohamed; Ayed, Manal Mohamed; Abdelkader Atia, Rania Reafaat; Aljadani, Saeedah H

doi:10.21608/asmj.2023.202043.1109

Effects of Whole Body Cooling and Magnesium Sulfate on Infants with Hypoxic-Ischemic Encephalopathy Treatment

Articles in Press

Document Type : Original Article

Authors

¹ sohag university

² pediatric nursing

³ Assistant professor of Physiology department Faculty of Medicine Zagazig University and Assistant professor of Basic Medical Science Faculty of Applied Medical Science

⁴ Department of Basic Sciences, Faculty of Applied Medical Sciences, Al-Baha University, Al-Baha, Saudi Arabia,

10.21608/asmj.2023.202043.1109

Abstract

In neonates with moderate-to-severe hypoxia-ischemia encephalopathy (HIE), Therapeutic hypothermia (TH), which can be achieved by either whole-body or localized head cooling, lessens brain damage, offers neuroprotection, and lowers mortality rates, especially if initiated within the first six hours after birth. Moreover, adjuvant therapy like magnesium sulfate (MS) management offers increased neuroprotection. Aim: to evaluate the effects of whole-body cooling and magnesium sulfate on infants with hypoxic-ischemic encephalopathy treatment. Patients and methods: 39 newborns who met the HIE criteria and were born in the Neonatal Intensive Care Unit at Sohag University Hospital were enrolled in the study. They were split equally across the three groups; During the first six hours of life, Group 1 (n 13) received whole-body cooling as the only therapy; In addition to MS, Group 2 (n 13) received whole-body cooling as adjuvant therapy, while Group 3 (n 13) received supportive acute care interventions as a comparison. Results: The TH plus MS group (group 2) had significantly better short-term outcomes when compared to other groups managed by TH (group 1) or supportive treatment, as indicated by a brief period of mechanical ventilation and respiratory support (p-value 0.001), a decrease in the incidence of convulsions (p-value 0.001), and an early start to feeding (p-value 0.001) (p-value 0.009) (group 3). Conclusion: In addition to MS, total body cooling is a safe therapy that enhances short-term clinical and radiological outcomes for the treatment of HIE infants.

Keywords

Main Subjects