Role of Serum Clusterin in Bronchial Asthma

Articles in Press

Document Type : Original Article

Authors

1 Clinical Pathology department Faculty of medicine Ain shams university

2 clinical pathology, faculty of medicine, ain shams university. cairo , egypt

3 clinical pathology department Faculty of medicine Ain shams university

4 Internal Medicine Department, Allergy and clinical immunology

5 Clinical pathology department Faculty of medicine Ain shams university

Abstract

Background: Bronchial asthma is known chronic inflammatory disease. Asthma is categorized into atopic asthma and non-atopic asthma based on absence or presence of atopy which is a positive skin prick test 3 mm or Immunoglobulin E (IgE) specific antibodies that are produced against common allergens. Oxidative stress has a role in pathogenesis of bronchial asthma. Clusterin is a glycoprotein chemokine and has a role in recruitment of inflammatory cells.
Aim of the Work: Our aim was to measure serum level of Clusterin in bronchial asthma patients including both (atopic and non-atopic) and to correlate it with the severity of the disease.
Materials and Methods: Case control study was done on (96) adult patients diagnosed with bronchial asthma (64 atopic and 32 nonatopic), in addition to (32) sex and age matched healthy controls. Serum Clusterin & IgE levels were measured using enzyme linked immunoassay.
Results: Clusterin level was higher in atopic and non atopic patients’ groups when each was compared to control group (p<0.01, respectively). Clusterin was elevated in severe atopic asthma compared to mild and moderate atopic patients (p=0.002 and 0.003, respectively). Clusterin was elevated in moderate non atopic asthma compared to mild non atopic patients (p=0.021). Multi-ROC of IgE and Clusterin at 23 IU/mL (IgE) and 20 ng/mL (Clusterin) showed diagnostic performance efficacy (98.4%) to differentiate between control and non-atopic group
Conclusion: Our study revealed that serum Clusterin can be a promising marker in diagnosis of bronchial asthma, and detection of degree of severity.

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Ain Shams Medical Journal

Articles in Press, Accepted Manuscript
Available Online from 01 October 2024

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