Evaluation of Ki67 Predictive Role and its Discordance Between Pretherapy Biopsy and Post therapy Surgical Specimen in breast cancer patients receiving neoadjuvant chemotherapy

Articles in Press

Document Type : Original Article

Authors

1 Clinical oncology and Nuclear Medicine Department Faculty of Medicine, Ain shams University

2 Department of Clinical Oncology and Nuclear Medicine Faculty of Medicine Ain Shams University

3 Assistant Professor of Clinical Oncology and Nuclear Medicine. Faculty of Medicine, Ain Shams University

Abstract

Background: Neoadjuvant chemotherapy (NAC) in breast cancer patients provides an excellent model for evaluation of potential predictive factors. Both clinical complete response (cCR) and pathological complete response (pCR) achieved after NAC is a surrogate marker for a favorable prognosis. Factors capable of predicting response such as the proliferation marker Ki67 may help improve our understanding of the drug response and its effect on the prognosis and survival.
Aim of the work: The aim of this study is to investigate the predictive value of the pretreatment Ki67 regard its ability to predict response to neoadjuvant chemotherapy and to investigate potential differences in proliferation scores between pretreatment core biopsies and post treatment final surgical samples in response to NAC.
Patients & methods: A Retrospective Study conducted on sixty (60) eligible Female Patients with Non metastatic Breast Cancer patients receiving NAC. in the period from January 2015 till January 2020 at breast clinic unit at Ain-Shams University Hospitals Clinical Oncology department. All Patient characteristics, clinical and pathological data and immunohistochemistry analysis and treatment related data were thoroughly collected.
Results: Pretreatment Ki-67 didn’t show any significant difference with both cCR and pCR. A significant decrease in Ki-67 expression from a median 25% in core biopsy prior to therapy to 12 % in surgical specimen after NAC in non-pCR patients
Conclusion: Pretreatment K-i67 level Couldn’t play a predictive role in predicting both cCR and pCR. A significant change in Ki-67 expression was observed between core biopsy and surgical specimen after NAC in breast cancer patients

Keywords

Main Subjects

Ain Shams Medical Journal

Articles in Press, Accepted Manuscript
Available Online from 01 October 2024

Files

Share

How to cite

Statistics