Inflammatory Markers and Gestational Diabetes Mellitus Risk: Investigating Neutrophil/Lymphocyte Ratio, Platelet/Lymphocyte Ratio, and Systemic Immune Inflammation Index

Document Type : Original Article

Authors

1 Aydın Adnan Menderes Unıversıty

2 Aydın Adnan Menderes Üniversitesi

3 yazar

10.21608/asmj.2024.290292.1273

Abstract

ABSTRACT

Aims: In the present study, we aimed to investigate the correlation of neutrophil to lymphocyte ratio(NLR), platelet to lymphocyte ratio(PLR), systemic immune inflammation index (SII) with the risk of gestational diabetes mellitus.

Material and Method: In this controlled cross-sectional study, 90 pregnant women with GDM and 110 uncomplicated, healthy, age- and body mass index-matched control pregnant women were evaluated. Oral glucose tolerance test (OGTT) for GDM diagnosis was performed at 24-28 weeks of gestation. fasting blood glucose (FBSG), fasting insulin and hemostasis model assessment of insulin resistance (HOMA-IR) values were compared in both groups.Levels of NLR, PLR, and SII were assessed.

Results: This study compares the blood parameters of women with diabetes mellitus (GDM) with those of a group of healthy subjects. In the GDM group, there was an increase in blood cell (WBC) and platelet (PLT) levels (p=0.009, p<0.001, respectively), as well as an increase in neutrophil and monocyte levels.Moreover, the NLR, PLR, and SII were markedly increased in the GDM group (p<0.001 for all). Conversely, lymphocyte levels were found to be decreased (p=0.005).

Conclusion: In the study, NLR, PLR, SII were significantly higher in patients with GDM. These parameters, which can be calculated with a simple haemogram test, can be used to predict GDM in the first trimester of pregnancy.

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