Document Type : Original Article
Authors
1
Rheumatology and Rehabilitation Department, Faculty of Medicine, Helwan University, Cairo, Egypt
2
Neurology Department, Faculty of Medicine, Helwan University, Cairo, Egypt
3
Internal Medicine Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
4
Internal medicine department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Abstract
Background: Antiphospholipid syndrome is a chronic, multi-system autoimmune disorder characterized by thromboembolic events and/or obstetric complications. Exploring associated risk factors is essential in management.
Aim of the Work: To study the lipid profile in antiphospholipid syndrome, and the effect of used medications on the lipid profile.
Patients and methods: A cross-sectional study was conducted on 70 patients with antiphospholipid syndrome recruited from Rheumatology-Rehabilitation and Neurology outpatient clinics and inpatient wards in four university hospitals. They underwent thorough history taking with complete physical examination. Laboratory investigations included: antiphospholipid markers, complete blood count, erythrocyte sedimentation rate, complement 3, complement 4, and fasting lipid profile. Dedicated imaging modality for diagnosis of arterial or venous thrombotic events
Results: Neurological manifestations (specifically migraine, sinus thrombosis and TIAs) showed a significant association with higher cholesterol levels. Sinus thrombosis was associated with lower HDL, higher TG, higher TG/HDL ratio and higher Cholesterol/HDL ratio. Lipid profile showed no statistically significant relation with received medications (Hydroxychloroquine, systemic steroids, and Azathioprine).
Conclusion: Dyslipidemia are common in APS especially in patients with TIAs, sinus thrombosis and migraine. No significant relation between medications used in treatment of APS and lipid profile levels.
Keywords
Main Subjects
)
View on SCiNiTO