Predictive Value of Red Cell Distribution Width-to-Lymphocyte Ratio for Diagnosis of Post Hepatic Cirrhosis

Document Type : Original Article

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Department of Gastroenterology and Hepatology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

10.21608/asmj.2025.353749.1371

Abstract

Background: As a promising noninvasive biomarker for diagnosing chronic hepatic diseases, including post-hepatatic
cirrhosis, the Red Cell Distribution Width-to-Lymphocyte Ratio (RDW-to-LR) has been emerged. Chronic liver diseases,
such as post-hepatatic cirrhosis, are associated with impaired liver function and pose significant global health challenges.
Traditional liver biopsy is invasive, highlighting the need for safer diagnostic approaches.
Aim: This study goal is to evaluate the RDW-to-LR predictive value in diagnosing post-hepatatic cirrhosis and explore its
potential mechanisms in reflecting pathophysiological modifications.
Methods: The study perfomed on 60 hepatitis B patients from Ain Shams University Hospital, divided into three groups: 30 with HBV-related cirrhosis, 30 healthy controls, and 30 with chronic hepatitis B, and. Laboratory evaluations measured total bilirubin, liver enzymes (ALT, AST), GGT.
Results: Regarding liver enzyme levels significant differences were found across the groups, with increased AST, ALT,
and GGT in the hepatitis and cirrhosis groups. Correlation analysis showed RDW-to-LR's association with liver function
parameters and its inverse relationship with hematological health indicators. Logistic regression identified RDW-to-LR as a significant predictor for cirrhosis. its high specificity and sensitivity in distinguishing cirrhosis from hepatitis and controls was confirmed via ROC analysis.
Conclusion: This study supports for diagnosing HBV-related cirrhosis the RDW-to-LR as a noninvasive, reliable biomarker.

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