Hyperdopaminergic Manifestations in Parkinson’s Disease: Correlation between Impulse Control Disorders and Levodopa- Induced Dyskinesia

Document Type : Original Article

Authors

1 Neurology Department , Faculty of Medicine, Ain Shams University

2 Sohag General Hospital

3 Neurology department , Ain Shams University , Faculty of Medicine

4 Faculty of Medicine, Ain Shams University

5 Neurology Department, Faculty of Medicine, Ain Shams University

10.21608/asmj.2025.357811.1383

Abstract

Objective: To explore the relationship between levodopa-induced dyskinesia and impulse control disorders (ICDs) in
Parkinson’s disease (PD), exploring the hyperdopaminergic motor and non-motor state.
Methods: A cross-sectional study was conducted on 30 PD patients with dyskinesia. All Participants were assessed by motor
and non-motor validated scales. These included the third part of the Unified Parkinson’s Disease Rating Scale owned by the movement disorders society MDS-UPDRS III, The Unified Dyskinesia rating scale (UDysRS) , Non -Motor symptoms scale for Parkinson’s disease (PD NMSS) in addition to dopamine dysregulation syndrome and impulse control disorders, cognition, depression and anxiety .
Results: The study group had a mean age of 58 ± 6.9 years, with 76.7% males. The mean disease duration was 8.8 ± 4
years. Impulse control disorders (ICDs) were observed in 60% of patients, with excessive medication intake being the most
common. All patients had moderate to severe motor symptoms, while the majority exhibited severe to very severe non-motor manifestations. A weak non-significant correlation (r = 0.194, p = 0.304) was found between levodopa-induced dyskinesia
assessed by UDysRS and Impulse control disorders assessed by the Questionnaire for impulsive compulsive disorders in
Parkinson’s disease (QUIP-RS), suggesting a possible association between both conditions.
Conclusion: While a non-significant positive correlation between dyskinesia and impulse control disorders was identified,
further studies are needed to explore the complex interplay between hyperdopaminergic motor and non-motor symptoms in Parkinson’s disease.

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