Document Type : Original Article
Authors
1
Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt
2
Pediatrics,faculty of medicine,ain shams university,cairo,egypt
3
Clinical Pathology, Faculty of Medicine, Ain Shams university, Cairo, Egypt
4
Department of Pediatrics, Faculty of Medicine, Ain Shams University
10.21608/asmj.2025.356833.1389
Abstract
Background: Asthma is associated with elevated cardiovascular disease risk, probably due to a common inflammatory
pathophysiology.
Objective: This study assessed serum anti-elastin antibodies and carotid intima-media thickness (CIMT) as systemic vascular
changes in asthmatic children and its correlation with asthma severity and control.
Patients and Methods: 70 children were enrolled in this prospective case-control study (35 asthmatic and 35 controls) from
the Pediatric Pulmonology Unit, Children’s Hospital, Ain Shams University, Cairo. They were subjected to a detailed history
taking, physical examination, the following investigations were done (CBC, CRP, serum IgE, serum Antielastin antibody as a
marker for vascular inflammation, carotid intima-media thickness by doppler ultrasound).
Results: Serum anti-elastin antibody levels were significantly higher in asthmatic group (69.11 ± 63.18 pg/ml) compared
to control group (6.61 ± 3.68 pg/ml) (P-value < 0.001), with significantly higher level of serum anti-elastin antibodies in
uncontrolled asthmatic children (91.16 ± 102.58 pg/ml) compared to controlled cases (51.05 ± 44.82 pg/ml) and partially
controlled cases (68.85 ± 53.88 pg/ml) (p-value <0.001). A statistically significant positive correlation was discovered between
serum IgE and anti-elastin antibodies (r= 0.774, p<0.001).
Carotid intima-media thickness (CIMT) among asthmatic children was (right 0.050 ± 0.008 cm, left 0.051 ± 0.007 cm)
compared to control group (right 0.048 ± 0.007 cm, left 0.048 ± 0.009 cm) with percentage of increase 4% in right carotid
artery and 5.4% in left one. No significant difference in mean CIMT between the right and left sides among asthmatic children
with different asthma control levels.
Conclusion: Serum Anti-elastin antibodies a vascular inflammatory marker, were higher in asthmatic children compared to
controls. This may require periodic follow up of any vascular changes in those patients.
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