The Relationship between Melanocortin 4 Receptor (MC4R) in Different Genes Polymorphisms with Obesity in Egyptian Population

Document Type : Original Article

Authors

1 Medicine Specialized Hospital, Faculty of Medicine, Mansoura University

2 Internal Medicine Department. Nephrology Unit, Faculty of Medicine, Damietta University, Egypt.

10.21608/asmj.2025.375304.1436

Abstract

Background: Obesity is a condition of an accumulation of excess of body fat potentially posing a threat of health and life in individual. Obesity is increasing in both developed and developing countries. It has a serious epidemic health problem, leading caused modulitity at global level.
Aim of the Work: This work aimed to study the relationship between MC4R gene polymorphism with obesity which has been identified through gene on Egyptian population.
Materials and Methods: This study investigates the interaction of MC4R on increasing obesity on adult population. In this population, rs17782313, rs12970134 and rs571312 gene polymorphism of melanocortin 4 receptor (MC4R) in obese and non-obese patients (n= 105 and 100, respectively) with age between 14 to 60 years were observed from Medicine Hospital inmates, University of Mansoura, Egypt. The lipid profile and body mass index (BMI), waist-to-hip ratio (WHR) were measured, the genotype of SNPS was obtained by restriction fragment length polymorphism (RFLP) method.
Results: A significantly higher of C/C, A/A and A/A, (p <0.0001, p <0.001, p <0.001) genotype was detected compared to controls of (rs17782313, rs12970134 and rs571312), respectively.
Conclusion: The MC4R of rs17782313 and rs12970134 and rs571312 single nucleotide polymorphism showed a strong relationship with obesity in Egyptian sample.

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Ain Shams Medical Journal
Volume 76, Issue 3
September 2025
Pages 573-581

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