Acceleration of Coronary Artery Disease in Patients with Previous COVID-19 Infections

Document Type : Original Article

Author

Cardiology Department, Faculty of Medicine AL Azhar University, Assiut, Egypt.

10.21608/asmj.2025.370619.1421

Abstract

Background: The pandemic COVID-19 has raised concerns about its impact on cardiovascular (CAV) health.
Aim: To evaluated the acceleration of coronary artery disease (CAD) in individuals with previous COVID-19 infections.
Methods: This retrospective cohort study examined 100 CAD patients at AL-Azhar University Hospitals from July 2023-2024. Participants underwent comprehensive evaluations including history, clinical examination, ECG, echocardiography, and coronary angiography. Primary outcome: incidence of CAD in COVID-19 patients. Secondary outcomes: CAD progression, inflammatory markers, endotحhelial function, and CAV events.
Results: The prevalence of CAD was much greater in individuals with previous COVID-19 (57.14%) than those without (30.56%, p=0.014), with increased arrhythmias (17.86% vs. 2.78%, p=0.017), and coronary artery calcium scores were significantly high in the COVID-19 group (p=0.030). There were no significant differences in hematological and biochemical parameters between both groups. Elevated inflammatory markers were noted but not statistically significant.
Conclusions: This research suggests an acceleration of CAD in patients with previous COVID-19 infections, characterized by increased prevalence, greater plaque presence, and elevated coronary artery calcium scores. These results underscore the importance of CAV monitoring in COVID-19 survivors.

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Ain Shams Medical Journal
Volume 76, Issue 3
September 2025
Pages 582-589

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